Clinical Application of Indocyanine Green Fluorescence Combined with Nanocarbon Tracing and Platinum Nanoparticles in Detection and Localization of Sentinel Lymph Node of Papillary Thyroid Carcinoma

Abstract

Objective: To explore the clinical application value of indocyanine green fluorescence combined with carbon nanotracer combined with platinum nanoparticles in the localization of sentinel lymph node (SLN) in papillary thyroid carcinoma (PTC). Methods: A total of 90 PTC patients who received surgical treatment were selected for this research. Indocyanine green fluorescence combined with nano-carbon and platinum nanoparticles was used prior to biopsy. The surgically resected sentinel lymph nodes and other dissected lymph nodes were frozen for pathological examination, and the related indexes of the two groups were compared. Results: The detection rate, accuracy and sensitivity of SLN in the observation group were significantly higher than that of control group. In addition, the false negative rate was significantly higher in control group. There was no significant difference in the average number of detected SLNs between the two groups. It was found that the patient’s gender, age, tumor size, tumor multifocality, TNM stage and other pathological parameters had no significant effect on the detection rate and accuracy of SLN. Conclusion: Indocyanine green fluorescence combined with carbon nanotracer and platinum nanoparticles as a lymph node tracer has good visibility and detection rate of SLN and has high value in clinical application value in SLN biopsy of papillary thyroid carcinoma.