Hyaluronic Acid-Modified Poly-Beta-Amino-Esters for Adriamycin Delivery Against Nasopharyngeal Carcinoma

Abstract

We developed a delivery system for highly efficient Adriamycin (ADM) use against nasopharyngeal carcinoma (NPC), based on Hyaluronic acid (HA)-poly-beta-amino-esters (PBAE). We used two NPC cell lines, CNE1 and CNE2, and nude mice plated with CNE1 as mouse models for in vitro and in vivo testing of the characteristics and function of ADM@HAPBAE. As a result, the average size of PBAE particles is found to be approximately 100 nm, and ADM@HA-PBAE has stability in environment with changing temperature and at pH = 7.4. In addition, ADM@HA-PBAE could deliver drugs to target lesion with high efficiency and showed high permeability to target areas, facilitating enough ADM release. In NPC cell lines, ADM@HA-PBAE could inhibit cell growth with high efficiency. In NPC mouse model, ADM@HA-PBAE could alleviate NPC growth and development and maintain a healthier physiological status, including body weight recovery, decreased tumor size and NPC inhibition. All these data suggest that ADM@HA-PBAE can increase ADM function by highly efficient targeting and delivery and should be considered as a potential strategy for NPC therapy.