Two Co(II) and Zn(II)-Related Coordination Polymers: The Diversity of Structure and Treatment Activity on Orthodontic Root Resorption Repair

Abstract

Co(II)- and Zn(II)-related coordination polymers (CPs): [Co(OPBT)(GA)]n (1) and {[Zn2TTPA(GA)2] · 2H2O}n (2), where TTPA represents tris(4-(1H-1,2,4-triazol-1-yl)phenyl)amine) and OPBT represents 1.1′-(oxybis(1,4-phenylene))bis(1H-1,2,4-triazole), were prepared through mixed-ligand synthesis. The raw materials were flexible glutaric acid (H2GA) with Co(II)/Zn(II) nitrate salts, TTPA, and bi- and tritopic 1,2,4-disparate triazole derivatives. The application value of the CPs in orthodontic root resorption repair was evaluated, and their relevant mechanisms were explored. ELISA assay was used in determining the content of tumor necrosis factor-α released in the gingiva groove. Then, real time RT-PCR was utilized in assessing whether the nuclear factor kappa-B inflammatory activity was activated. Additionally, the CCK-8 method was used in investigating positive effects on osteoblast proliferation. Finally, the expression of the wnt protein in osteoblasts was detected with Western blotting assay.