Study on the Pathogenesis of Dengue Hepatitis

Abstract

Dengue virus (DENV) is a single-stranded RNA virus that is transmitted by Aedes aegypti and Aedes albopictus. As a global health problem, early diagnosis and timely treatment of DENV are imperative. Therefore, it is important to explore the association between dengue fever and hepatitis and its pathogenesis and development mechanism of action. This may lead to the identification of biological markers for the prevention and treatment of dengue fever-induced hepatitis. In this study, we identified differentially expressed genes associated with interferon signaling to further understand the relationship between dengue fever and hepatitis. It has been speculated that during dengue-induced hepatitis, DEXD/H-box helicase 58 (DDX58) and interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) are primarily responsible for pathogen identification. The joint action of HECT and RLD domain containing E3 ubiquitin protein ligase 5 (HERC5) and ubiquitinspecific peptidase 18 (USP18) regulate the biological effects of interferon and participate in the occurrence and development of this disease.