Supramolecular Mn(III) Coordination Polymer with Treatment Activity on Diabetic Retinopathy

Abstract

A new Mn(III) coordination polymer formulated as [Mn2(L)2Cl2(DMF)2]n (1, H2L is 2,2′-bipyridyl-6,6′-dicarboxylic acid; DMF is N,N′-dimethylformamide) was solvothermally prepared using Mn(ClO4)2 · 6H2O, H2L, and (CH3)4NCl as raw materials. The assay of SCXRD for 1 suggests that it features a 0D isolated dinuclear [Mn2(L)2Cl2(DMF)2] structure that exists in P-1 with triclinic system, and the cell parameters are a = 8.4593(2), b = 9.4675(5), c = 11.0147(6) Å, α = 86.023(3), β = 74.892(6), γ = 78.055(4)°, V = 833.11(7) Å3, and Z = 1. These isolated 0D dinuclear [Mn2(L)2Cl2(DMF)2] motifs were extended into a 1D supramolecular chain via the connection of intermolecular C–H…Cl together with the C–H…O H bond. Furthermore, the novel CP’s treatment activity against the diabetic retinopathy was investigated, and the associated mechanism of the new compound was discussed.