miR-134 Inhibits Cervical Cancer Cell Invasion via Targeting Cortactin

Abstract

Cervical cancer is a common malignancy, and miR-134 involves in multiple tumors. The present study aims to explore its expression and role in cervical cancer. miR-134 level in cervical cancer and para-carcinoma tissues was detected by RT-PCR. Cells were transfected with miR-134 mimics or inhibitor followed by measuring cell behaviors. The results of bioinformatics analysis showed that miR-134 targeted the downstream CTTN. miR-134 inhibited the biological behaviors of cervical cancer cells through suppressing the downstream cell division cycle 42 (Cdc42)/neural Wiskott-Aldrich syndrome protein (N-WASP) signals. Moreover, miR-134, through regulating CTTN, negatively regulated invasion and inhibited the degradation of extracellular matrix in cervical cancer cells. In conclusion, miR-134 targets CTTN to inhibit the invasion of cervical cancer, thereby inhibiting metastasis.