Comparison of the Efficacy of HYAFF11 Mesh with Collagen Membranes in Guided Bone Regeneration

Abstract

This study aimed to evaluate the efficacy of HYAFF11-based meshes in guided bone regeneration (GBR). Two defects of 5-mm width were prepared in the calvaria of 36 rats. The rats were divided into the following groups: empty defect (group E); HYAFF11-based mesh (group HY), collagen membrane (group CM), xenograft (group X), xenograft+HYAFF11 mesh (group X+HY), and xenograft+collagen membrane (group X+CM). Sacrifications were performed at the third and sixth post-surgical weeks, followed by histological evaluation. The highest amount of new bone (NB) formation in the third week was observed in group X+CM (0.94±0.40 mm2), followed by group X+HY (0.80±0.21 mm2). The highest amount of NB formation in the sixth week was observed in group X+CM (1.57±0.66 mm2), followed by groups X and X+HY (1.39±0.48 mm2 and 1.34±0.44 mm2, respectively). There was no statistically significant difference in the amount of residual graft between groups X+HY, X+CM, and X at the third and sixth weeks. Considering the close values observed between the groups, it could be concluded that HYAFF11 may be an alternative biomaterial for use in GBR. Further studies using different graft materials and defect sizes are required to evaluate the effectiveness of HYAFF11 in GBR.