Novel Approach of Phyto-Mediated Thermo-Sensitive and Biocompatible Nano-Formulation to Improve Anti-Microbial Efficacy Against Pathogenic Bacterial for the Treatment of Wound Infections

Abstract

Design and development of novel methods for the synthesis of metal nanopartilces (MNPs) was greatly attracted by research community due to various applications. We described a greener strategy for the synthesis of silver nanoformulation (Ag NF) using leaf extract of Ziziphus zizyphus and then surface functionalized using P(NIPAM-co-MQ). The synthesized AgNPs were characterized by UV-visible spectroscopy and Transmission electron microscopy. Further, the functionalized AgNPs were characterized XPS and x-ray diffraction studies. The design of bioactive and biocompatible Ag nanoformulation preparations have been provide promising alternative source for bacterial-related therapies. The developed Ag NF have demonstrated predominant bactericidal action with highinhibition rate and long-term efficiency against clinically approved bacterial pathogens (S. aureus and E. coli), which greatly contributed treatment of wound infections. The observations of the present study could provide new avenue for the antimicrobial treatment of wound therapy