Physical Characteristics and Cellular Pharmacological Activity of Baicalin-Lecithin Complex-Loaded Poly(lactic-co-glycolic acid) Membranes

Abstract

In this study, the physiochemical properties and cellular-level biological effects of baicalin-lecithin complex (BLC)-loaded poly(lactic-co-glycolic acid) (PLGA) membranes were studied. Several parameters were measured to evaluate the preparation of these membranes, such as the coating thickness, scanning electron microscopy-detected surface morphology, X-ray diffraction, Fourier transform infrared spectroscopy, and thermodynamic behavior. The drug-release behavior was mainly controlled by the degradation of the PLGA. The release of BLC lasted for more than one month, which matched the development of the restenosis process. The BLC-coated PLGA (60:40) membrane had good drug release in terms of its long release cycle, and the efficacy of baicalin in the form of BLC in cardiovascular stents matched the development of restenosis. In vitro cell culture test showed that endothelial cells (ECs) and smooth muscle cells (SMCs) for 12 h, 1 d and 3 d, BLC-loaded PLGA membranes (1%, 5% and 10% (w/w)) had significant activity towards the proliferation of ECs and the inhibition of SMC proliferation (P < 0.05). BLC-loaded PLGA film has good drug release trends.