Transplantation of Bone Marrow Mesenchymal Stem Cells (BMSCs) Improves Nerve Cell Function in Rats with Cerebral Infarction and Injury

Abstract

Our study intends to assess the effect of transplantation of bone marrow mesenchymal stem cells (BMSCs) on nerve cell in rats with cerebral infarction and injury. 36 healthy rats were separated into JS group (sham-operation), NG group (cerebral infarction) and YZ group (BMSCs transplantation). The arrangement of brain tissue in JS group was integrated without edema and confused in NG group with obvious edema. However, the necrosis degree of brain tissue in YZ group was alleviated. There were symptoms of muscle loss in the right foreleg and hind leg of rats in NG group. The NSS score in NG group was higher than JS group (P < 0.05), suggesting that the neurological function after BMSCs transplantation was improved. The distribution of cortical tissue was tight and nervous tissue distribution in NG group was evacuated comparatively. The quantity of nerve cell was reduced with tumescence. In conclusion, transplantation of BMSCs exerts a promising therapeutic effect on the treatment of cerebral infarction as it can improve nerve cell function, reduce oxidative stress and inflammatory cytokines secretion, and ameliorate cerebral injury.