Synthesis and Characterization of Murraya koenigii Linn Formulation for Potential Topical Application
-
Published:2018-08-01
Issue:8
Volume:24
Page:5891-5896
-
ISSN:1936-6612
-
Container-title:Advanced Science Letters
-
language:en
-
Short-container-title:adv sci lett
Author:
Banerjee Kaushita1,
Kamat Nandita1,
Pearline Diana1,
Thiagarajan Narayanaswamy2,
Thiagarajan Padma1
Affiliation:
1. School of Biosciences and Technology, VIT University, Vellore 632014, India
2. Material Science Division, CSIR National Aerospace Laboratories, Bangalore 560017, India
Abstract
Murraya koenigii Linn leaf (curry leaf) is a favored spice known for its medicinal, therapeutic, nutraceutical and cosmetic properties. Its oil formulations have emerged as a favorable base for controlled delivery of actives by topical route of administration. However, most of
such formulations include several synthetic chemicals as emulsifiers and stabilizers that may be hazardous in the long run. In the present study, curry leaf oil formulation with an alkyl polyglucoside emulsifier has been formulated for potential dermatological applications. Ultrasonication
was employed for reduced particle size and better efficiency. The formulation was characterized for mean particle size, polydispersity index zeta potential and electrophoretic mobility. FTIR analysis of the oil confirmed the presence of the functional groups of its constituents as identified
by GC-MS and revealed the prevalence of extensive hydrogen bonding in the formulation. Its SEM image showed the structural topography. The viability of different concentrations of the oil, tested on dermal fibroblasts cells (3T3 cell lines), was found to be from 97% to 20%. The accelerated
stability tests confirmed the formulation’s non-susceptibility to various destabilization mechanisms after a period of 180 days at 37 °C, or under low speed centrifugation. Furthermore, the formulation was stable when stored at 40 °C, 4 °C and −18 °C for 3 cycles.
Thus, this bio based formulation can either be used as such or as a base matrix for loading active ingredients for topical delivery.
Publisher
American Scientific Publishers
Subject
General Energy,General Engineering,General Environmental Science,Education,General Mathematics,Health(social science),General Computer Science