Observation on the effect of high-quality nursing intervention in gadolinium-based sodium material adjuvant radiotherapy for non-small cell lung cancer

Abstract

Non-small cell lung cancer (NSCLC) is a common malignant tumor. Because of the concealment of its early clinical symptoms, most of the patients are diagnosed at the middle and advanced stages. Nowadays, the NSCLC has become one of the critical factors affecting the quality of life of Chinese residents. Traditional radiotherapy cannot meet the clinical treatment needs of NSCLC patients. Here, we used gadolinium oxide (Gd2O3) as a new radiosensitizer matrix and introduced paclitaxel (PTX), with excellent anticancer cell migration function to construct paclitaxel-gadolinium oxide nanoparticles (PTX-Gd2O3 NPs). The clinical experiments show the unique nanometer radiation dose enhancement effect and radiosensitive function of PTX-Gd2O3 NPs. The new nanodrug can successfully exert the secretion of thrombin-sensitive protein-1 of PTX, thereby inhibiting the proliferation and migration of tumor cells, which is expected to provide a new direction for treating long-term NSCLC.