Construction of high sensitivity electrochemiluminescence sensor and its application in NT-proBNP detection

Abstract

Amino terminal pro-brain natriuretic peptide (NT-proBNP) is an important biomarker for clinical diagnosis, risk stratification, prognosis evaluation, and efficacy monitoring in patients with acute and chronic heart failure. Traditionally, NT-proBNP detection is based on immunochromatography, which is time-consuming, tedious, requires professional-trained operators, etc. Here we developed a simple, fast, unlabeled, highly sensitive, and low-cost carbon nanotubes (CNTs)@Au NPs-modified electrochemiluminescence NT-proBNP sensor, and evaluated its feasibility in the clinical monitoring of cardiac function in patients with heart failure. Notably, the sensor has a small batch size difference and good reproducibility and can be used for mass production. The device offers a new opportunity and direction for the clinical monitoring of NT-proBNP.