Therapeutic effect of multifunctional nano-liposomes on Alzheimer’s disease

Abstract

Curcumin (Cur), an active phenolic compound in Zingiberaceae, is a fat-soluble natural medicine with a significant curative effect on Alzheimer’s disease (AD). However, Cur has low water solubility, resulting in low bioavailability. In this study, a new type of multifunctional nano-liposome was developed and designed to increase the bioavailability of Cur. Using hyaluronic acid (HA) as the carrier, a transferrin-hyaluronic acid-curcumin (Tf-HACur) nanoliposome was prepared by loading transferrin (Tf) targeting agent and Cur to treat AD. Tf-HA-Cur has very low cytotoxicity. Behavioral and molecular results show that Tf-HA-Cur can cross the blood-brain barrier and effectively treat AD. The nanoliposome provides a new strategy for the delivery of drugs.