Construction of lidocaine transmembrane nano-liposomes and preliminary study on its surface anesthetic effect

Author:

Zhang Lirong1,Li Wei1,Zhao Qingjun2,Teng Ruyang3

Affiliation:

1. Department of Anesthesiology, Weifang Traditional Chinese Hospital, Weifang 261000, Shandong, PR China

2. Department of Anesthesiology, Jinan Zhangqiu District People’s Hospital, Jinan 250200, Shandong, PR China

3. Department of Anesthesiology, Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong, PR China

Abstract

Lidocaine (Lido) is an amide local anesthetic that has both excitatory and inhibitory effects on the central nervous system, and is one of a group of commonly used local nerve block drugs that are used in the clinic. However, traditional Lido does not meet the transdermal performance requirements of surface anesthetic agents for treating pain in patients. Optimizing the preparation of a Lido transdermal preparation and improving the control of anesthetic depth and efficiency has become a challenge in the field of topical anesthesia. In this study, a new type of Lido nano-transdermal preparation, carboxymethyl chitosan-modified lidocaine liposomes (Lido-CMCSNLP), were constructed based on nano-liposomes. Carboxymethyl chitosan can enhance the permeability of hydrophilic macromolecular pathways by interacting with negatively charged membrane glycoproteins, which is beneficial for the transdermal absorption of Lido. Therefore, Lido-CMCS-NLP provides a new approach for research in clinical topical anesthesia and perioperative topical analgesics.

Publisher

American Scientific Publishers

Subject

General Materials Science

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