Human papillomavirus genotyping and vaginal microbial metabolites in 276 patients with atypical cervical squamous cells and the clinical effect of nano-silver after loop electrosurgical excision procedure

Abstract

Cervical intraepithelial neoplasia (CIN) is a precancerous lesion of cervical malignant tumors. CIN is closely related to persistent human papillomavirus (HPV) infection, sexual behavior, and number of childbirths. The effect of vaginal microbial metabolites (VMM) on CIN is unclear; hence, we studied the effects of VMM and high-risk HPV (HR-HPV) infection on CIN and the clinical effects of nano-silver after loop electrosurgical excision procedure (LEEP). We selected the patients who went to the obstetrics and gynecology department of our hospital from January 2019 to November 2020, and we conducted vaginal microbiology, HPV typing, and histopathological examination on 282 patients. Among them, six patients had cervical cancer, 136 patients with CIN were regarded as the CIN group, and 140 patients with normal pathological tissue were regarded as the normal group. The results showed that H2O2 and HR-HPV infection were significantly correlated with the risk of CIN (P < 0.05). LEEP was performed on CIN patients, and the treatment with nano-silver gynecological antibacterial suppository was postoperatively compared with patients without special treatment. The results show that postoperative treatment with nano-silver can shorten the bleeding and exudation time of the wound and promote wound healing. It can simultaneously reduce wound infection and promote HPV to become negative, which can effectively reduce postoperative complications and recurrence.