Study on the removal of amyloid plaque by nano-gold in the treatment of neurodegenerative disease-alzheimer’s disease

Abstract

As a complex neurological disease, the treatment of Alzheimer’s disease (AD) is a global challenge. Compared with traditional drug therapy, a novel therapeutic tool, inorganic nanoparticles combined with photothermal therapy (PTT) can decompose amyloid β-protein (Aβ) fibrils and inhibit Aβ aggregation, alleviating AD symptoms. In this study, MoS2@Au NPs composite nanoparticles were constructed by combining sulfhydryl-modified Au NPs and MoS2 nanosheets. In vitro experiments showed that the composite nanoparticles could degrade insoluble Aβ fibers to soluble monomers and alleviate neurotoxicity. Additionally, the excellent biocompatibility and biosafety of MoS2@Au NPs reduced the damaging effects on nerve cells, and the AD model mice benefited from the treatment with MoS2@Au NPs, which significantly improved their learning and cognitive abilities and thus reduced the disease. More importantly, MoS2@Au NPs combined with PTT effectively curbed the inflammatory response and slowed down the course of AD.