In situ thermoresponsive curcumin-loaded dual polymeric nanoassemblies for wound healing and care of femoral fracture after surgery

Abstract

Approximately 6.3 million fractures occur annually in the United States. Fractures (for example, hip fractures) occur in 2.4% population per year. A new clinical solution to this issue is the use of biomaterials with a dual purpose of bone healing and prevention of infection. In this study, advanced biomedical curcumin nanoparticles combined with a copolymeric matrix that had a dual function were developed and shown to promote antiinflammatory, functional recovery, and successful neuroprotective effects. The application of curcumin nanoparticles packaged in a thermoresponsive drug carrier device improves sustainability, bioavailability of blood, longevity, and biocompatibility. This nanocomposite showed enhancement of neuroprotection, axonal growth performance, and theoretically, functional recovery at the location of femoral fracture injury, by curcumin-primed polycaprolactone (PCL) (Cur-CS@PCL). Various microscopic methods (SEM, TEM, and LS) verified the morphology and shape of the manufactured Cur-CS@PCL nanoassemblies. In addition to these membranes being used at different temperatures, they improved the drug charge films and exhibited better-regulated release profiles for Cur. Thus, our data provide a simple hybrid clinical approach for the prevention and rehabilitation of femoral fractures in humans.