Affiliation:
1. Department of Neurology, Inner Mongolia People’s Hospital, Hohhot 010017, China
2. Department of Biological Science and Technology, Baotou Teacher’s College, Baotou 014030, China
Abstract
Hyperuricemia is closely related to acute ischemic stroke (AIS). In our study, we investigated the pattern of miRNA-155-5p and miRNA-124-5p expressions along with its clinical application in AIS and hyperuricemia patients and in a hyperuricemia rat model by RT-qPCR. The hyperuricemia
rat model was established, and we found that the levels of miRNA-155-5p and miRNA-124-5p were increased in the serum, brain and kidney tissues compared with those in the normal rats. We proved that the levels of miRNA-155-5p and miRNA-124-5p were also elevated in AIS, hyperuricemia and AIS
accompanied with hyperuricemia patients enrolled from the department of neurology in Inner Mongolia People’s Hospital (IMPH). The miRNA-155-5p and miRNA-124-5p were mainly associated with neuronal apoptosis, cerebral vasospasm, neuron projection, neuron projection morphogenesis, neuron
differentiation and exocytosis. The above results might provide clues for the study the pathogenesis of AIS and hyperuricemia.
Publisher
American Scientific Publishers
Subject
General Materials Science