Design of chitosan-poloxamer nanogel and evaluation of its therapeutic effect on skin burn

Abstract

Wound infection is the main cause of slow healing and complications of skin burns. Wound dressings can temporarily replace the skin to isolate the contamination and can be anti-infective, which is conducive to wound healing. In this study, a chitosan-Poloxamer-apigenin nanogel dressing (CTS-Plo-Api) was constructed using CTS and Plo, as carriers, and Api. In comparison with traditional treatments, the speed of wound healing is improved with the use of CTS-Plo-Api; moreover, it enhances bacteriostatic and anti-infection ability and has certain analgesic effects. Therefore, we demonstrate that CTS-Plo-Api is an exciting new clinical avenue for the treatment of burn patients.