Effects of High-Concentration Alkali Treatment on Surface Bioactivity of Porous Titanium

Abstract

Various surface treatment methods have been used to modify the surface activation of dense titanium. In this study, a high concentration of sodium hydroxide solution was used to treat porous titanium prepared by adding porous agent at different times. The results of the study showed that after alkali treatment, porous titanium was implanted into the back muscle of the dog and the implanted sample was taken out for bone formation protein-2 enzymatic immunoassay after 6 months. The porous titanium inner wall has been covered. The microstructures vary with the treatment time. The treated surface can induce the formation of hydroxyapatite deposition and promote the expression of BMP-2, which shows good bone induction. High concentration alkali treatment of porous titanium, the method is simple, can shorten the HA formation time, can effectively activate porous titanium inner and outer surfaces, is an effective method to prepare bioactive porous titanium.