Expression of miR-93 and Glucose Transporter Type 4 Mediated by Ginkgolide in Peripheral Blood with Polycystic Ovary Syndrome and Its Clinical Significance

Abstract

Decreased Glucose transporter 4 (GLUT4) expression leads to abnormal glucose regulation. miR-93 regulates GLUT4 expression and studies have shown that, ginkgolide mediates miR-93 and GLUT4 in polycystic ovary syndrome (PCOS). 50 patients with PCOS and 50 healthy women were recruited. RT-qPCR detected miR-93 and GLUT4 expression. Luteinizing hormone (LH) (11.84 ± 4.08), T (76.87±30.24), FINs (20.06±11.37) and HOMA-IR (3.75±1.04) in the PCOS group was higher than control group (7.42±3.63, 43.58±13.9, 8.74±4.62, 1.55±0.39) (P < 0.05). miR-93 expression in peripheral blood of PCOS group was significantly elevated, while GLUT4 mRNA expression was reduced (P < 0.05). miR-93 negatively correlated with GLUT4. miR-93 in insulin resistance (IR) group was higher than non-IR group, while GLUT4 was lower (P<0.05). miR-93 positively correlated with T (r=0.374, P =0.019), FINs (r=0.322, P =0.026) and HOMA-IR (r = 0.507, P = 0.005), while GLUT4 had a negative correlation. miR-93 and GLUT4 are abnormally expressed in PCOS, which is related to complications such as IR and endocrine metabolism.