Anti-Cancer Activity and Mechanism of Resveratrol Against Triple-Negative Breast Cancer

Abstract

This research analyzed the antitumor of resveratrol in triple negative breast cancer (TNBC). TNBC were divided into control group and resveratrol group. Tnbc-associated TNBC cells were stimulated by different concentrations of resveratrol, and the proliferation, apoptosis, migration of the cells were analyzed. The amount of migration was measured by Transwell method. The PI3K, Akt, and mTOR were detected. Results showed that the cell apoptosis was obvious and the invasion ability was decreased in resveratrol group, and the effect was more obvious with the increase of dosage, and there was a statistical difference between groups (P < 0.05). Resveratrol significantly decreased the expression of Akt, PI3K and mTOR, and there were statistical differences between groups (P < 0.05). In summary, resveratrol reduces cell migration, promotes cell apoptosis, inhibits cell proliferation, and its mechanism is closely related to the blocking of PI3K/Akt/mTOR.