Affiliation:
1. Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Hebei, Cangzhou, 061001, China
2. Cangzhou Third Hospital, Cangzhou, 061001, China
Abstract
BHRS has been employed in clinical settings for the treatment of T2DM. However, the precise underlying mechanism of its action remains elusive. In this study, we elucidate the specific therapeutic effects of BHRS on T2DM and subsequently investigate its mechanism using untargeted metabolomics
techniques. Our research demonstrates that BHRS modulates the levels of 22 metabolites, including alpha-ketoglutaric acid, L-ascorbate, and L-ornithine, among others. These metabolites primarily participate in metabolic pathways involving nicotinate and nicotinamide, arachidonic acid, and
inositol phosphate. In conclusion, our findings establish that BHRS effectively lowers blood glucose levels, mitigates inflammatory responses, and attenuates oxidative stress in T2DM rats. Additionally, BHRS influences the metabolic pathways of nicotinate and nicotinamide, arachidonic acid,
and inositol phosphate in the serum of T2DM rats.
Publisher
American Scientific Publishers