Affiliation:
1. Heilongjiang Provincial Key Laboratory of Cereal and Comprehensive Processing of Cereal Resources, School of Food Engineering Harbin University of Commerce, Harbin 150076, China
2. School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China
Abstract
Polysaccharides extracted from sweet corncob (SCP) were modified by sulfuric acid to sulfated sweet corncob (SSCP) with a molecular weight of 13.412 kDa, and their antiglycation activity was studied. SSCP had high inhibitory effects on glycation and showed antiglycation activity stronger
than that of SCP in vitro. The maximum inhibition rates of the Amadori products, dicarbonyl compounds, caboxymethyl-lysine (CML), and advanced glycation end products (AGEs) were 76.35, 73.78, 52.79, and 76.36%, respectively. SSCP effectively increased body weight, reduced blood glucose,
and increased oral glucose tolerance in streptozotocin (STZ)-induced diabetic rats in vivo. Furthermore, SSCP inhibited AGE formation in liver tissue and repaired pancreatic injury. The results in vivo and in vitro reflect that SSCP has antiglycation effects, which may
be closely related to its antidiabetic effects.
Publisher
American Scientific Publishers
Subject
Renewable Energy, Sustainability and the Environment,Biomaterials,Bioengineering
Cited by
1 articles.
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