Targeted delivery of protein binding polyethylene glycol-polylactic acid nanoparticles for the treatment of cerebral thrombosis

Abstract

To study and analyze the suitability of protein binding polyethylene glycol-polylactic acid nanoparticles (PEGPLA-NPs) for the treatment of cerebral thrombosis, and its influence on platelet parameters. Patients with cerebral thrombosis admitted to our hospital from April 2017 to May 2018 were randomly divided into the control and observation groups. Data on the clinical history and blood parameters of the patients were compared. After treatment with the protein binding PEG-PLA-NPs, the plasma viscosity and whole blood viscosity of the observation group were significantly higher (p < 0.002) than those of the control group. The effective rate (93.3%) in the observation group was significantly higher than that of the control group (71.1%). The nanoparticles were characterized by high drug loading, high encapsulation efficiency, suitable preparation and purification methods, optimal particle size and shape, and controlled drug release. Protein binding PEG-PLA-NPs, therefore, could be suitable modalities for the treatment of cerebral thrombosis, and be effective in improving patient conditions and subsequent rehabilitation.