Study on the antipyretic effect of gypsum and its compatibility on yeast-induced pyrexia rats based on NF-κB signaling pathway

Abstract

To research the antipyretic function of gypsum and its compatibility on yeast-induced pyrexia rats based on NF-κB signaling pathway, the rat model of fever was replicated by subcutaneous injection of 20% yeast suspension in the back of the rat. Gypsum, Anemarrhenae, gypsum and Anemarrhena or aspirin was administered by gavage. Gypsum and its synergist reduced the body temperature of febrile rats significantly, and reduced the levels of fever-producing medium Prostaglandin E2 (PGE2) and pyrogenic factors including tumor necrosis factor(TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6) in rat serum also the level of central heating medium PGE2 in cerebrospinal fluid (CSF). Furthermore, we demonstrated that gypsum and Anemarrhena concerted application inhibit NF-κB signal pathway in yeast-induced pyrexia rats. The results indicate that gypsum and its Anemarrhena concerted application may be a potential antipyretic and the antipyretic mechanism is attributed to the suppression of NF-κB signal pathway.