Synthesis of Magnetic Hydrogels for Target Delivery of Doxorubicin

Abstract

Magnetic hydrogels are the stimuli responsive polymeric networks with potential applications in protein purification, cell separation and target drug delivery. In the present investigation, efforts are made on synthesis and characterization of magnetic hydrogels from poly(N-isopropylacrylamide) for onwards application in target delivery of an anticancer drug Doxorubicin. Formation of reaction products was ascertained through diversified spectral methods. Ultraviolet spectra reveal in vitro biocompatibility of Doxorubicin that imparts sustained delivery up to 72 hrs at pH 7.2 ± 0.2 under ambient conditions. The present investigation provides an inexpensive method of synthesis of magnetic hydrogels suitable for magnetically derived delivery of anticancer drugs.