The Effect of POSS-COOH/Silicone Rubber (SR) on the Adipogenesis Differentiation of Mesenchymal Stem Cells
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Published:2019-06-01
Issue:6
Volume:9
Page:760-769
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ISSN:2157-9083
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Container-title:Journal of Biomaterials and Tissue Engineering
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language:en
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Short-container-title:j biomater tissue eng
Author:
Du Yichen,Shi Xiaohua,Zhou Xin,Chen Yao,Wang Hailin,Zhang Yiming,Fan Dongli
Abstract
The aim of this study was to prepare an engraving silicone rubber (SR) material with good biocompatibility and functionality. SR with different POSS-COOH proportions was produced by mixing POSS-COOH nanoparticles in medical liquid silicone. The viability, adhesion and differentiation
of MSCs on the surface of the modified materials were examined. Compared with virgin SR, the hydrophilic property of the composites was obviously increased and hardness was decreased; however, there was no obvious change in the surface morphology of the POSS-COOH/SR. The results of MTT showed
that the viability of MSCs on POSS-COOH/SR was significantly suppressed (P < 0.05). Furthermore, POSS-COOH/SR was able to induce significant adipogenesis differentiation of MSCs. Our results demonstrated POSS-COOH/SR not only improves cell compatibility, it promotes the adipogenic
differentiation of MSCs. It may be used as a new soft tissue-filling material in the field of plastic surgery.
Publisher
American Scientific Publishers
Subject
Biomedical Engineering,Medicine (miscellaneous),Bioengineering,Biotechnology
Cited by
1 articles.
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