Sodium Alginate Microspheres Tissue Metabolism and Correlation Between Interventional Treatment of Liver Cancer Using Alginate Microspheres and Prognosis of Liver Cancer

Abstract

To explore the effect of tissue metabolism of sodium alginate microspheres on liver cancer and the correlation between interventional treatment of liver cancer using alginate microspheres and prognosis of liver cancer in rabbits, in order to provide reliable data for human clinical study. Rabbit liver cancer model was established through direct inoculation of liver cancer tissues. Rabbits in experimental group were treated with hepatic arterial embolization (HAE) as follows: sodium alginate microspheres was injected through femoral artery to three sites which was 0.5 cm (proximal), 2 cm (middle), and 3.5 cm (distal) far from the lesion, respectively to block the tumor's nutrient supply. Short-term clinical efficacy, 3 month survival rate, 6-month mortality rate, 1-year survival rate, and adverse reactions were measured. The complete remission rates of proximal group, middle group, and distal group was 80%, 40%, and 20%, respectively. The complete remission rate of proximal group was significantly higher than that of middle group or distal group, with significantly higher complete remission rate of middle group compared with distal group (P < 0.05). In terms of progress, a significant difference was seen between proximal group and distal group (P < 0.01). 3-month and 1-year survival rates were increased along with the decrease of distance from injection position to the lesion with the correlation equation of y = –15.567x + 104.47 (R2 = 0.9429) and y = –13.333x + 91.133 (R2 = 0.9639). Six-month mortality rate was decreased along with the decrease of distance from injection position to the lesion with the correlation equation of y = 15.343x – 5.9967 (R2 = 0.9943). The prognosis was correlated with the injection position of alginate microspheres. The closer the injection position to the lesion, the better prognosis.