Photobiomodulation Therapy in Mitigating the Risk of SARS CoV-2 Infection by Enhancing Biodiversity of Oral Microbiome-A Conceptual Hypothesis Based on Scoping Review

Abstract

Since March 2020, scientists across the globe are looking for ways to combat COVID-19, a viral disease of recent times which was declared Pandemic by WHO. Mounting an incompetent immune reverberation and the surge in pro-inflammatory cytokines are the main cause for complications. Hence, it is hypothesized that photobiomodulation therapy (PBMT) using low-level light therapy (LLLT) might be a successful therapeutic treatment for COVID-19 victims since it has been shown to be successful in enhancing immunity, aiding in tissue healing, and reducing pro-inflammatory cytokines. The goal of this scoping review is to investigate the potential use of PBMT as a promising neo-strategy for an alternative therapy for the treatment of patients with COVID-19 in light of the significance of underlying pathways in the mitigation, therapeutic interventions, and recovery of chronic diseases like COVID-19. The findings of the review revealed that PBMT using a low-level laser has been proven to be effective in treating COVID-19’s initial stages and prevent the progression to severe form of the disease. This approach needs to be confirmed by clinical trials and larger studies that include a wider population. Because of its proven effectiveness in reducing inflammation, thrombosis and accelerate wound healing, PBMT may be a promising approach to reduce the severity of COVID-19, especially in the lungs. Based on the findings of the review, we propose a novel hypothesis of utilizing PBMT to enhance the biodiversity of oral microbiome which will help in extenuating the imperilment of SARS CoV-2 infection.