MicroRNA-153 Restrains Cell Metastasis and Epithelial–Mesenchymal Transition in Cervical Carcinoma by Targeting SATB1 and Regulating Wnt/<i>β</i>-Catenin Pathway-Reference-Cited by-同舟云学术

MicroRNA-153 Restrains Cell Metastasis and Epithelial–Mesenchymal Transition in Cervical Carcinoma by Targeting SATB1 and Regulating Wnt/β-Catenin Pathway

Published:2024-02-01 Issue:2 Volume:20 Page:398-405
ISSN:1550-7033
Container-title:Journal of Biomedical Nanotechnology
language:en
Short-container-title:j biomed nanotechnol

Author:

Liu Wenfeng¹,Zhang Meng²,Du Xiaojie³,Zhang Min⁴,Wang Weiling⁵,Zhang Zhiying⁶

Affiliation:

1. Department of Gynaecology, Jinan City People’s Hospital, Jinan People’s Hospital Affiliated to Shandong First Medical University, Jinan, 271100, China

2. ICU Department, Affiliated Qingdao Central Hospital of Qingdao University, Qingdao Cancer Hospital, Qingdao, 266000, China

3. Department of Outpatient, Affiliated Qingdao Central Hospital of Qingdao University, Qingdao Cancer Hospital, Qingdao, 266042, China

4. Department of Health Management, Jinan Zhangqiu District People’s Hospital, Jinan, 250200, China

5. Department of Ultrasound, Jinan Zhangqiu District People’s Hospital, Jinan, 250200, China

6. Health Examination Department, Yantaishan Hospital, Yantai, 264003, China

Abstract

As a malignant tumor, cervical cancer (CC) seriously affects women’s life and health. Various microRNAs (miRNAs) are involved in tumorigenesis of CC. Here, we mainly paid attention to the effect of miR-153 in CC. RT-qPCR or Western blot was employed to quantify miR-153 or SATB1 expression. Molecular mechanism of miR-153/SATB1 was detected by Transwell and dual-luciferase assays. MiR-153 was downregulated in CC. Furthermore, upregulation of miR-153 restrained cell metastasis. Upregulation of SATB1 was detected in CC, and negative connected with miR-153 in CC cells. Knockdown of SATB1 suppressed cell metastasis in CC. The inhibitory effect of miR-153 was abolished by upregulation of SATB1. Besides that, miR-153 blocked EMT and downregulated p-β-catenin expression in CC cells. MiR-153 restrains cell metastasis and EMT in CC by targeting SATB1 and regulating Wnt/β-catenin pathway.

Publisher

American Scientific Publishers

Reference49 articles.