Analysis of Clinical Diagnostic Value of Dynamic Contrast-Enhanced Magnetic Resonance Imaging Combined with MRI in Early Breast Cancer

Abstract

A study involving 73 patients with early breast space-occupying diseases (41 malignant, 32 benign) utilized 1.5T quantitative dynamic enhanced magnetic resonance imaging to measure lesion-specific parameters. These included the contrast medium’s transfer rate from intravascular to extravascular (Ktrans), return rate to blood vessels (Kep), and tumor vessel volume fraction (Vp). Pathological results post-surgery served as the gold standard. Comparisons between benign and malignant groups, as well as malignant subtypes, were made. Malignant lesions exhibited varied Ktrans (0.108–2.810 min−1) and Vp (0.0018–0.743 ml) values. Benign lesions had Ktrans (0.125–2.472 min−1), Kep (0.008–1.760 min−1), and Vp (0.006–0.816 ml) values. Significant differences were observed in Ktrans and Vp (P < 0.05), but not in Kep and Vp (P > 0.05). While differences between hormonal and HER2 statuses were minimal, Kep in HER2-positive tumors was notable (P < 0.05). Subtype comparisons showed no significant Ktrans variation (P > 0.05) but differences in Kep and Vp. In conclusion, Ktrans is crucial for diagnosing early breast cancer and distinguishing between benign and malignant diseases. The study underscores the potential of quantitative dynamic contrast-enhanced MRI in breast cancer diagnosis