Combination of Focused Ultra Sound and MnO2/GOD Loaded Microbubble Nanoparticles in Targeted Tumor Therapy of Breast Cancer

Abstract

In order to increase the absorption of anticancer medications into malignancies in a noninvasive and targeted way, focused ultrasound in conjunction with microbubble (MB) might improve drug delivery. Here, we test two exemplary focused ultrasound-driven drug delivery enhancement approaches (MB and Doxorubicin-coated nanoparticle complex using MnO2/GOD) and confirm their acute drug delivery augmentation. Experiments were performed utilizing the MDA-MB-231 breast cancer cell line in an in vivo animal model. We observed that MB containing Doxorubicin-coated nanoparticle using MnO2/GOD complex increased Doxorubicin concentrations in tumors. These findings suggest that MB and MB nanoparticle based anticancer drug delivery may considerably enhance the efficacy of anticancer medications given to tumors in a short period of time using low-intensity focused ultrasound.