Study on Inhibition of Glioma Tumorigenesis by Circular RNA Mitogen-Activated Protein Kinase 1 via miR-587/Dipeptidyl Peptidase 9 Regulatory Pathway

Abstract

Accumulating evidence verified that, circular RNA MAPK1 (Hsa_circ_0004872) is involved in tumorigenesis, and whether circMAPK1 is involved in glioma remains unclear. circMAPK1 was markedly downregulated in glioma tissues. Upregulation of circMAPK1 attenuated activities of glioma cells. Moreover, circMAPK1 could bind miR-587, which was upregulated in glioma cells. DPP9 was a downstream gene for miR-587, indicating that, DPP9 upregulation inhibits glioma progression, while downregulation of DPP9 abolished circMAPK1 overexpression effect on glioma cell growth. Our discoveries demonstrated that, the circMAPK1 is a tumor suppressor by regulating the circMAPK1/miR-587/DPP9 signaling pathway in glioma, and circMAPK1 might be a potential biomarker or target for glioma diagnosis and therapy.