Treatment activity of hydrogels loaded with copper metal–organic frameworks of dacarbazine on melanoma by modulating melanoma prognostic markers S100A6 and VEGFa

Abstract

In the present paper, a new Cu(II)-based coordination polymer (CP) with the chemical composition of [Cu2(μ4btca)(phen)2(H2O)2]n (1) was synthesized and successfully loaded with the drug dacarbazine. Based on the chemical synthesis method, HA/CMCS hydrogels loaded with copper metal–organic frameworks of dacarbazine were prepared. SEM results showed the hydrogels had a typical macroporous structure with good penetration between the pores. The results of the CCK-8 assay showed the hydrogels could substantially reduce the viability of the melanoma cells. In addition, the hydrogels reduced the migration and invasive ability of cancer cells in a dose-dependent manner by suppressing the expression of melanoma prognostic markers VEGFa and S100A6, which is a promising application for the treatment of melanoma.