Synthesis and gelation character of photothermal responsive methylcoumarinotripeptidospiropyran

Abstract

Hydrogel of methylcoumarino-tripeptidospiropyran (MC-TPSP) with a conformational transition at the C-terminus of the peptide was synthesised in this study. This LMWG can be shifted between gel and solution due to the isomerization of spiropyran- and merocyanine-typed MC-TPSP and MC-TPMC, respectively. UV was used to investigate the isomerisation process, and SEM was used to characterise the morphology of the MC-TPMC. The transition temperature was determined to be 75 °C, and the minimum gel concentration was 14.5 mM. On account of its structural biocompatibility and responsive regulatory mechanism, it is anticipated that it will develop into an outstanding bio-functional material.