Antioxidant and anti-inflammatory properties of pine pollen extract promote wound healing

Abstract

Wound healing is a complex cascade reaction process which is frequently delayed or non-healed due to oxidative stress and persistent inflammation. As a natural antioxidant, pine pollen has potential antioxidant and anti-inflammatory benefits. In this study, we demonstrated that pine pollen extract can promote collagen formation, angiogenesis, granulation tissue and hair follicles regeneration, and regulate inflammatory process. Moreover, pine pollen extract performed significantly better than control group in antioxidant and anti-inflammatory features. In addition, the concentration of 1 mg/mL is more conducive to promote wound healing. These findings indicated that pine pollen extract has high antioxidant and anti-inflammatory activity which could speed up skin tissue regeneration and promote wound healing, being useful in regenerative medicine.