Adsorption of porcine pulmonin can reduce the toxicity of gold nanorods and reduce lung injury

Abstract

It is well known that porcine lung phospholipid injection (Curosurf) can effectively inhibit lung inflammation and reduce inflammatory cell damage to lung tissue, but whether it can reduce nanoparticles damage to lung remains to be seen. Poractant was co-incubated with gold nanorods as the model particle in this study to adsorb poractant on the surface of gold nanorods. Elisa kit was used to determine the adsorption degree of human lung surfactant associated protein poractant on the surface of gold nanorods. Gold nanorods adsorbed human lung surfactants associated proteins were evaluated further in vitro and in vivo. The toxicity of gold nanorods after absorption of porcine lung phospholipid was studied using human normal lung epithelial cells BEAS-2B; TNF- and IL-1 in serum were studied after absorption of porcine lung phospholipid using acute lung injury as a model. The results of the experiments show that adsorption of porcine lung phospholipids can reduce the toxicity of gold nanorods and the lung damage caused by gold nanorods.