Preparation and application of amphiphilic polymer nanomaterials for ischemic injury

Abstract

With the increasing popularity of competitive sports, martial arts routines have attracted great attention. However, myocardial ischemic injury is one of the most common sports-related diseases in martial arts routines. In this study, γ-Fe2O3 nanoparticles were used as a treatment for myocardial injury. The safety of these nanoparticles was determined by assessing apoptosis rates and reactive oxygen species levels in myocardial cells, as well as biochemical indicators such as lactate dehydrogenase and superoxide dismutase. The results showed that the aforementioned indicators were normal, indicating that γ-Fe2O3 nanoparticles are safe for myocardial cells. Additionally, the application of γ-Fe2O3 nanoparticles to hypoxic environments significantly improved anti-hypoxia ability, alleviated calcium overload in myocardial cells, and reduced intracellular reactive oxygen species content, thereby protecting myocardial cells from hypoxia damage. Therefore, this study provides an effective strategy for treating ischemic injury in martial arts athletes and establishes an experimental foundation for the clinical management of myocardial ischemic injury.