Liensinine improves cognitive function of gastric cancer under dexmedetomidine anesthesia by inhibiting neuron apoptosis through synuclein

Abstract

Surgical resection is the main treatment approach for gastric cancer (GC), but surgical anesthetics may have an impact on postoperative cognitive function. Therefore, this study investigated the effect of liensinine on neuronal apoptosis and cognitive function in mice with GC induced by dexmedetomidine anesthesia. Firstly, a GC mouse model was established and divided into the following groups; blank control group, GC model group, low-dose (4 μmol/L) and high-dose (8 μmol/L) groups of liensinine (n = 6), to detect apoptosis of neurons. In addition, the GC model group, Synuclein (SYN) mimic group, SYN inhibitor group, high-dose neusinine group, and high-dose liensinine+SYN inhibitor group were set up with 6 rats in each group. The cognitive function of mice after treatment was observed by Morris water maze experiment, and neuronal cell apoptosis and expressions of SYN, brain-derived neurotrophic facto (BDNF) and Caspase-3 were explored. Liensinine significantly improved the cognitive function of GC mice after dexmedetomidine anesthesia, and this process is related to decreased SYN expression. Liensinine can inhibit increased SYN expression, so apoptosis of neurons in the hippocampus of mice was controlled after the use of SYN inhibitors, especially in the high-dose liensinine+SYN inhibitor group. Liensinine down-regulated the expression of SYN and inhibited the Caspase-3 to reduce neuronal cell apoptosis, promoting recovery of BDNF level, and then playing role in improving the cognitive function of GC mice after dexmedetomidine anesthesia.