Therapeutic Activity of Aspirin-Loaded Poly(lactic-co-glycolic acid) Microspheres Against Coronary Heart Disease

Abstract

Coronary heart disease is the most dangerous heart disease worldwide, and its morbidity and mortality rates are rising. Aspirin is the most clinically used anti-platelet-aggregation agent, preventing thrombosis and reducing the incidence of cardiovascular events. Accordingly, the development of drug-delivery systems containing aspirin is an urgent problem to be solved. In this study, PLGA microspheres with excellent biocompatibility were prepared based on the emulsification–volatilisation method by using aspirin as a drug model. PLGA/aspirin microspheres had small size, high sphericity, and high drug-loading rates. Its therapeutic activity and nursing application value against coronary heart disease were evaluated, and the related mechanism was explored.