Two-Dimensional Layered Zn(II) Metal–Organic Framework as Photocatalyst for Lupus Nephritis Therapy

Abstract

A new Zn(II) metal–organic framework formulated as [Zn3.5(SO4)2(μ3-OH)2(1,2,3-tz)(H2O)2]n (1, 1,2,3-Htz = 1,2,3-triazole) was subjected to solvothermal integration and structural modification. Semiconductive property was confirmed by UV-Vis diffuse spectrum, which showed an optical band gap of 2.68 eV. The solid specimen of 1 used as a photocatalyst exhibited outstanding photocatalytic performance with regard to MV degradation in aqueous solution during UV light illumination. The potential of the photocatalyst for lupus nephritis therapy and the underlying mechanism were investigated. ELISA revealed that FcyR II accumulated in plasma. The percentage of apoptotic renal epithelial cells was also measured with flow cytometry.