New Luminescent Zn(II)-Based Complex with Preventive and Inhibitory Effects on Skin Cancer

Abstract

The dual ligand of 5-(1-oxoisoindolin-2-yl)isophthalic acid (H2L) and 1,2-bis(4-pyridyl)ethane (bpe) was combined with Zn(II) ions in a DMF-H2O system to produce a Zn(II) compound, i.e., (Zn[L][bpe])n (1). At room temperature, compound 1 is luminescent with luminescent quantum yield of 35.8% and luminescence lifetime of 10.5 ns. For the treatment of skin cancer, its suppression effect against skin cancer was discussed, and the mechanism was investigated. The CCK-8 assay was used to detect the CP’s suppression effect against skin cancer cells. Moreover, real-time RT-PCR was conducted to examine the relative CA19-9 expression in cancer cells.