Nanoparticle Albumin-Bound Paclitaxel is More Effective Than Paclitaxel in Experimental Endometrial Cancer

Abstract

Nab-paclitaxel is a water-soluable formulation of paclitaxel. It is more effective and less toxic than paclitaxel in treating cancer. Here we compared nab-paclitaxel with paclitaxel for their antitumor efficacy and toxicity in vitro and in a murine endometrial cancer model. Nab-paclitaxel was more effective than paclitaxel in inhibiting cancer cell growth. Nab-paclitaxel also caused cell apoptosis and cell cycle G1 arrest more effectively than paclitaxel. Similar effect was observed in mice model of endometrial cancer. In summary this preliminary study shows nab-paclitaxel is a promising therapeutic agent for endometrial cancer and deserves further studies.