Protection and Nursing Values of 2D/3D Lanthanide Coordination Polymers on Ischemic Injury by Reducing Myocardial Cell Apoptosis

Abstract

In this work, two lanthanide metal coordination polymers (CPs) with Ho ions as metal centers were successfully prepared via the reaction between metal salt HoCl3·6H2O or Ho(NO3)3·6H2O and the ligand of 4-(pyridyl-N-oxide)methylphosphonic acid (H2L) under solvothermal conditions. Their chemical formulae are {[Ho2(L)2(H2O)5]2Cl·2H2O}N (1) and [Ho(L)(OH)(H2O)]N (2). Their bioactivity and mechanism were analyzed for possible application as ischemic injury treatment. First, percentage of the apoptotic myocardium was determined with flow cytometry after treatment using the compound. The activation for the signaling pathway of PI3K/Akt in myocardium was also examined by real-time RT-PCR.