Regulating Structures of Two Co(II)-Based Coordination Polymers: Application Value in Sepsis Therapy by Inhibiting Inflammatory Response

Abstract

Two coordination polymers (CPs) based on Co(II), [Co(L)(bipy)] ·3H2O (1), and [Co(L)(phen)(MeOH) (H2O)2] · 0.5H2O (2) were successfully generated under solvothermal reactions. These CPs were characterized via infrared spectroscopy, elemental analysis, single-crystal X-ray diffraction, and X. The regulation of these CPs’ structures was compared by introducing different lengths of nitrogen-donor auxiliary ligands. The corresponding mechanism in the regulation of these structures was elucidated. The CPs’ suppression activity against the release of inflammatory cytokines was detected via ELISA. Subsequently, the relative expression of p53 and nf-κb in immune cells after treatment with the CPs was detected via real-time PCR. Finally, the application value of these novel CPs in sepsis therapy was explored.