Preparation, Mechanism and Bioactivity of Nano-Hydroxyapatite/Poly(DTH carbonate) Composite Bone Repair Material

Abstract

A novel nano-hydroxyapatite/poly(desaminotyrosyl-tyrosin-hexyl ester) carbonate composites bone cement was prepared using nano-hydroxyapatite and poly(desaminotyrosyl-tyrosin-hexyl ester) carbonate. The experimental results indicate that the compressive strength of the nano-hydroxyapatite/poly(desaminotyrosyl-tyrosinhexyl ester) carbonate composite bone cement which contained bone can reach 18.2 MPa, which can satisfy the repair demand of cancellous bone parts. Nano-hydroxyapatite and poly(desaminotyrosyl-tyrosinhexyl ester) carbonate are combined by hydrogen bonding. Calcium citrate is formed by reaction of Ca2+ in nano-hydroxyapatite with the carboxyl group in citric acid. The nano-hydroxyapatite/poly(desaminotyrosyltyrosin-hexyl ester) carbonate composite bone cement was soaked in simulated body fluid to form hydroxyapatite. The results of the cell culture experiment and animal implantation indicated that nano-hydroxyapatite/poly(desaminotyrosyl-tyrosin-hexyl ester) carbonate composite bone cement had good biocompatibility and osteogenesis capability. This study is useful for the development of nanohydroxyapatite/ poly(desaminotyrosyl-tyrosin-hexyl ester) carbonate composite materials in the field of bone repair.