New Luminescent Cd(II) Coordination Polymer and Its Protective Activity on Alzheimer’s Disease

Abstract

A novel coordination polymer has been created smoothly in the hydrothermal environments, and its formula is [Cd(L)2(H2O)]n (1, HL = 4-((2-methyl-1 H-imidazol-1-yl)methyl)benzoic acid). The analysis for the structure of X-ray indicates the coordination polymer 1’s 1D infinite chain architecture, which is further developed into a 2D layer through hydrogen bond interactions. Moreover, the 1’s luminescent property and thermal function were explored. For the experiment of Alzheimer’s disease, the enzyme linked immunosorbent assay was applied for evaluating the vascular endothelial growth factor C (VEGF-C) content delivered to the cerebrospinal fluid. The neuron apoptosis was also evaluated via the Annexin V-FITC/PI apoptosis assay after compound treatment.