Wound Healing Capacity of the n-Butanolic Extract ofCentaurea tougourensisBoiss. & Reut.

Abstract

Plants are considered an inestimable source of therapy, and one of the oldest. The structural elucidation of phytocompounds allowed the scientific community to elaborate on new effective drugs, which has considerably enriched the international pharmacopoeia and allowed society to overcome several epidemic and pandemic situations.Centaureaspecies demonstrated over the years a remarkable capacity to treat several illnesses related to inflammation, oxidative stress and even cancer. This study aimed to evaluate the wound healing capacity of the n-butanol (n-BuOH) extract ofCentaurea tougourensisusing a formulation approach, during a period of 18 days. Male Swiss Albino mice were used for this purpose and the wound area was calculated using Image J software. In addition, macroscopic and histopathological analyses were performed. The study revealed a considerable healing process for the two tested concentrations (200 and 400 mg/kg) of the plant extract, reaching at the end of treatment a percentage reduction in wound area of (91.82%) and (99.80%) respectively, noting that no sign of inflammation was detected in the group of mice treated by plant extract. This study demonstrated once again the pharmacological properties of this species.